Free Radicals and the LiverGeza Csomos, Janos Feher Springer Science & Business Media, 2012 M12 6 - 157 páginas Based on the results of the latest congress of the European Association for the Study of the Liver (EASL), this volume makes excellent reading since it explores in detail the role of free radical reactions in liver diseases. Studies in recent years using various methods have shown that free radicals play an important role in toxic liver disorders. For this reason, the current scientific knowledge is presented in this balanced, clinical portrayal. The account refers to the many observations, experiencesand evaluations that have been made both clinically and experimentally. Two major areas discussed concern the pathophysiological changes by free radicals and the therapeutic possibilities that have come to light. |
Contenido
Liver Injury Caused by Drugs and Chemicals | |
LipidPeroxidation as aCauseofCell Damage Lipid Peroxidation andDerangement of Calcium Homeostasis | |
References | |
Relationships Between Free Radical Reactions and the Functionof the Cytochrome P450 System | |
Regulation Mechanisms of Xenobiotics Metabolizing Liver | |
Effect ofCCl 4on Free Calcium of Liver Cell Cytosol | |
References | |
Free Radical Reactions in the Pathomechanism of Amiodarone | |
Lipid Peroxidation and Associated Hepatic Organelle | 14 |
Results and Discussion | 16 |
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Términos y frases comunes
acid Acta activity Adriamycin alcoholic amiodarone antioxidant aroxyl radicals Biochem Pharmacol Biophys bleb calcium carbon tetrachloride carbonyl CCl4 cell injury Chem chemicals chemiluminescence chromanoxyl radicals chronic compounds concentration conjugated cytochrome P450 cytoprotection damage decrease Dianzani effect electron endoplasmic enzyme experimental Fatrich diet fatty Fehér flavonoids formation free radical reactions freeradicals function glutathione hemochromatosis hepatic hepatocellular hepatocytes Hepatology hepatotoxicity hydroperoxides hydroxyl hyperlipidemic increased incubation Inhibition inhibitors inthe iron overload isolated hepatocytes isozyme kaempferol leukotrienes lipid peroxidation lipid peroxidationand lipoxygenase liver cell liver disease liver injury liver microsomes luminol lysosomal malondialdehyde mechanisms metabolism microsomal mitochondrial MTDQDA NADPH oflipid ofthe oxidase oxidative stress P450 reductase pathogenesis pathological peroxyl phospholipids Prostaglandin protection proteins rat liver reactive oxygen species redox cycling reduction role Ruckpaul scavenging serum silibinin solution spin structure studies substrate superoxide theliver tissue tothe toxicity toxigenic ubiquinones vitamin vitro vivo xenobiotics